Volume of Distributor (Vd): 0.86 L/kg +/- 0.15 L/kg
Volume of Distribution (Vd): 1.3 L/kg +/- 0.4 L/kg
Protein binding: approximately 50%
Protein binding: low
Alcohol dehydrogenase and glucuronyltransferase
Metabolites:5′-carboxylic acid, 5′-glucuronide, and carbovir triphosphate
Metabolite: trans-sulfoxide metabolite and lamivudine triphosphate
Renal: (intravenous) approximately 70% unchanged
: 1.45 hour+/- 0.32 hour
: approximately 5 hour to 7 hour
Hepatic decompensation may occur.
Sometimes fatal hypersensitivity reactions have occurred.
Immune reconstitution syndrome has been reported.
Use not recommended in patients with impaired
Fetal risk cannot be ruled out.
Infant risk cannot be ruled out.
counts, ALT, AST, and total
load, fasting lipid profile, urinalysis
How to Take or Administration
The National Institute for Occupational Safety and Health (NIOSH) recommends the use of single gloves by anyone handling intact
or administering from a unit-dose package.
In the preparation of
, including cutting, crushing, or manipulating, or the handling of uncoated
, NIOSH recommends the use of double gloves and a protective gown. Prepare in a ventilated control device, if possible. Use respiratory protection if not prepared in a control device. During administration, wear single gloves, and wear eye/face protection if the formulation is hard to swallow or if the patient may resist, vomit, or spit up.
NIOSH recommends the use of double gloves and a protective gown by anyone handling a hazardous oral liquid or any hazardous drug via a feeding tube. Prepare in a control device, if possible. Use respiratory, eye, and face protection if not done in a control device. During administration, eye/face protection is needed if the patient may resist, or if there is potential to vomit or spit up.
Take with or without food.
) 600 MG-300 MG
Patient Counselling or Clinical Teaching
Instruct patient to immediately report symptoms of an
Warn patient to immediately report symptoms of
Advice patient to consult physician before resuming therapy if there is an interruption in therapy.